Losmapimod (GW856553X)
- Product Name
- Losmapimod (GW856553X)
- CAS No.
- 585543-15-3
- Chemical Name
- Losmapimod (GW856553X)
- Synonyms
- CS-1186;GSK-AHAB;SB856553;GW-856553;LosMapiMod;GW 856553X;SB0856553);MIS-21394 LOSMAPIMOD;LosMapiMod,GW-856553;Losmapimod (GW856553X)
- CBNumber
- CB32484670
- Molecular Formula
- C22H26FN3O2
- Formula Weight
- 383.46
- MOL File
- 585543-15-3.mol
Losmapimod (GW856553X) Property
- Boiling point:
- 529.4±50.0 °C(Predicted)
- Density
- 1.20±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in EtOH; insoluble in H2O; ≥19.15 mg/mL in DMSO
- form
- solid
- pka
- 7.75±0.46(Predicted)
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 13614
- Product name
- GW 856553X
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $34
- Updated
- 2024/03/01
- Product number
- 13614
- Product name
- GW 856553X
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $67
- Updated
- 2024/03/01
- Product number
- 13614
- Product name
- GW 856553X
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- 13614
- Product name
- GW 856553X
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $249
- Updated
- 2024/03/01
- Product number
- L471000
- Product name
- Losmapimod
- Packaging
- 50mg
- Price
- $340
- Updated
- 2021/12/16
Losmapimod (GW856553X) Chemical Properties,Usage,Production
Description
GW 856553X is a dual inhibitor of p38α and p38β MAPK (Kis = 0.0079 and 0.025 μM, respectively, in cell-free assays). It is selective for p38α and p38β MAPK over p38γ and p38δ MAPK when used at a concentration of 10 μM. GW 856553X inhibits LPS-induced TNF-α production in isolated rat and human peripheral blood mononuclear cells (PBMCs; IC50s = 0.6 and 0.13 μM, respectively). It decreases disease severity in a mouse model of collagen-induced arthritis when administered at doses ranging from 0.8 to 20 mg/kg. GW 856553X (1.2 and 12 mg/kg) improves survival, normalizes blood pressure, and reduces increases in plasma levels of HDL, LDL, and triglycerides in spontaneously hypertensive stroke-prone rats fed a high-salt high-fat diet.
Uses
Losmapimod is a selective, potent, and orally active p38 MAPK inhibitor.
Definition
ChEBI: 6-[5-[(cyclopropylamino)-oxomethyl]-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide is a phenylpyridine.
target
p38α
References
[1]. willette rn, eybye me, olzinski ar, et al. differential effects of p38 mitogen-activated protein kinase and cyclooxygenase 2 inhibitors in a model of cardiovascular disease. j pharmacol exp ther, 2009, 330(3): 964-970.
[2]. cheriyan j, webb aj, sarov-blat l, et al. inhibition of p38 mitogen-activated protein kinase improves nitric oxide-mediated vasodilatation and reduces inflammation in hypercholesterolemia. circulation., 2011, 123(5): 515-523.
[3]. lomas da, lipson da, miller be, et al. an oral inhibitor of p38 map kinase reduces plasma fibrinogen in patients with chronic obstructive pulmonary disease. j clin pharmacol, 2012, 52(3): 416-424.
Losmapimod (GW856553X) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Losmapimod (GW856553X) manufacturers
- Product
- Losmapimod 585543-15-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Losmapimod 585543-15-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- Losmapimod (GW856553X) 585543-15-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2019-12-23